Alzheimer’s Disease Essay examples -- Alzheimers Disease Essays

Alzheimer’s disease is a neurodegenerative disorder affecting memory, cognitive and non-cognitive functions. Studies show that most cases of Alzheimer’s disease pertains to people who are 60 years of age or older; meanwhile, 80% of these cases are due to genetics. The risk of one having Alzheimer’s disease varies with their age and ethnicity. That being said, some elders are obtaining this disease in very late life, nearing their 90’s. The gene that is usually responsible for Alzheimer ’s disease (AD) is the Apolipoprotein E (APOE gene) which gets its name from encoding for the protein Apolipoprotein. It is on chromosome 19 and has three main alleles on the gene that seem to be responsible for this disease. They are: ÃŽ µ2, containing cysteine at position 112 and arginine at position 158 of the gene, ÃŽ µ3 containing cysteine at both 112 and 158 positions, and ÃŽ µ4 containing arginine at both 112 and 158 positions of the gene. The APOE ÃŽ µ4 allele is the disease’s most prevalent allele. The APOE ÃŽ µ4 allele is the disease’s most prevalent allele. The function of this gene is to regulate cholesterol and triglyceride metabolisms. This shows it is not only coincidental that high cholesterol and diabetes lead to late-onset Alzheimer’s. The APOE ÃŽ µ4 allele was tested and discovered to be so dangerous in 1993. Since, many more studies have been completed on this allele and it has been known to be the main cause of Alzheimer’s disease. Once all the human genotype was known after using the Human Genome Project, a microarray system used to study over 80 percent of the Caucasian genome for association signals called the 500K GeneChip from Affymetrix was created. This microarray kit was used to confirm that using high-density single nuc... ...sion, the results point researchers in the right direction proving that late on-set Alzheimer’s is very closely related to this APOE locus, especially the ÃŽ µ4 allele. Further studies may also show that this allele will likely contribute to other diseases as well. With the use of ultra-high density genome, further associations will be made regarding the link between late on-set Alzheimer’s and the APOE locus. Works Cited Coon, Keith D. Ph.D.; Amanda J. Myers, Ph.D.; David W. Craig, Ph.D.; Jennifer A. Webster, B.A.; John V. Pearson, B.Sc.; Diane Hu Lince, Ph.D.; Victoria L. Zismann, M.S.; Thomas G. Beach, M.D.; Doris Leung, M.D. â€Å"A High-Density Whole-Genome Association Study Reveals That APOE Is the Major Susceptibility Gene for Sporadic Late-Onset Alzheimer’s Disease.† Physicians Post Graduate Press. J Clin Psychiatry 68:4, April 2007: 613-618. (Print)

Gender Communication Differences in Traditional Marriage Essay

Men and women communicate differently. Two people of opposite gender joined in marriage have two very different styles of communication to the extent that this problem is sometimes insurmountable. Lack of clear communication between partners in a traditional marriage is often cited as the cause for divorce. What often occurs â€Å"is not a failure to communicate, but a failure to understand communication† (Akin, 2003, 1). Long before technology took over society and created more avenues for communicating with each, men were used to showing support by â€Å"doing things† for the family and women showed their affection through talking (Torrpa, 2002, 1). Women expect their marital relationship to be based on mutual dependence and cooperation while men expect it to be based on independence and competition (Torppa, 2002, 1). Clearly, these two different sets of expectations will have an effect on how the two partners communicate and ultimately, on the strength of the union. According to Ohashi (1993) marriage is a system established on the assumption of a division of labor based on gender-role stereotypes (from Katsurada, Sugihara, 2002, 2). Women traditionally tend to want to â€Å"make everyone happy† while men make decisions based largely on their own personal needs (Torrpa, 2002, 1) – one aspect of marriage that is unchanged for the most part yet responsible for many breaks in communication between the partners. Differences in characteristic gender roles also affect communication between husband and wife. Typically, women are characterized as being the more talkative of the sexes as well as being comfort providers and more secure in showing their emotions. Women are also better at â€Å"reading between the lines† regarding interpersonal issues (Torrpa, 2002, 1). Men, on the other hand, are known for their distinct lack of communication and inability to provide emotional support. Their ability to â€Å"read between the lines† regarding status is more pronounced than in women. With traditional roles in marriage declining and technology taking over, communication is at once both more effective and less available (Morris, 2001, 1) – we have more ways of communicating (e. g. text messaging, Email, etc. ) but we have less time to do so with multiple careers. Both male and female partners tend to see the other as being more controlling of the relationship (Torppa, 2002, 1) and without the ability to communicate effectively, this assumption can be quite damaging to the marriage. This research will explore the varying roles of a man and woman in a traditional marriage relationship, how these roles influence their ability to effectively communicate, and the level of satisfaction each partner feels based on their idea of whether or not they are communicating effectively with each other regarding important issues. According to Torrpa (2002, 1): â€Å"understanding differences is the key to working them out†. B. Hypothesis It is expected that marriage partners with traditional roles (i. e.the husband as breadwinner, the wife in charge f the household) will experience a greater chasm between what is being said and what is meant in that these partners will have communication styles more typical of their gender. It is hypothesized that men will have a very different style of communication than the women in each partnership. C. Participant Selection A minimum of 15 married alumni couples will be identified via public records office and sent a mailed invitation. Commitment may also be obtained via telephone. Respondents to the survey will be offered a gift card from a local merchant. D. Materials 1) Written questionnaire regarding the couple’s marriage 2) Assessment of task completion using a scale model E. Procedure In this study, the married couples will be surveyed regarding their role in the marriage. Each couple will be surveyed individually. A task will be randomly and privately assigned to one of the partners with specific instructions to verbally communicate the specifics of the task to the other partner. Communication style and effectiveness will be measured by the ability of the spouse to complete the task and a post-task survey completed by the spouse that will rank the value of the instructions given on a scale of one to 10. The spousal differences between the style of communication (i. e. non-verbal direction, logic) will be made apparent by the answers to the post-task survey. Analyzing the data with frequency tables is expected to show that the males in the group communicate using logic, while the females will rely more on non-verbal signals they expect their partner to recognize. Potential Risks to Participants There are no potential risks associated with participation in this research study. However, should participants feel the need for counseling services following the survey, they will be directed to the campus counseling center. G. Expected Benefits for Participants and Society Participants in the survey should garner a much better idea of how to communicate more effectively with each other. The hope is that through awareness of communication deficits, the married couples will be able to put this new knowledge to use when needing to communicate about larger and more important issues.

The Vampire Diaries: The Struggle Chapter One

â€Å"Damon!† Icy wind whipped Elena's hair around her face, tearing at her light sweater. Oak leaves swirled among the rows of granite headstones, and the trees lashed their branches together in frenzy. Elena's hands were cold, her lips and cheeks were numb, but she stood facing the screaming wind directly, shouting into it. â€Å"Damon!† This weather was a show of his Power, meant to frighten her away. It wouldn't work. The thought of that same Power being turned against Stefan woke a hot fury inside her that burned against the wind. If Damon had done anything to Stefan, if Damon had hurt him†¦ â€Å"Damn you, answer me!† she shouted at the oak trees that bordered the graveyard. A dead oak leaf like a withered brown hand skittered up to her foot, but there was no answer. Above, She turned – and gasped. He was just behind her, so close that her clothes brushed his as she turned. At that distance, she should have sensed another human being standing there, should have felt his body warmth or heard him. But Damon, of course, wasn't human. She reeled back a couple of steps before she could stop herself. Every instinct that had lain quiet while she shouted into the violence of the wind was now begging her to run. She clenched her fists. â€Å"Where's Stefan?† A line appeared between Damon's dark eyebrows. â€Å"Stefan who?† Elena stepped forward and slapped him. She had no thought of doing it before she did it, and afterward she could scarcely believe what she had done. But it was a good hard slap, with the full force of her body behind it, and it snapped Damon's head to one side. Her hand stung. She stood, trying to calm her breath, and watched him. He was dressed as she had first seen him, in black. Soft black boots, black jeans, black sweater, and leather jacket. And he looked like Stefan. She didn't know how she could have missed that before. He had the same dark hair, the same pale skin, the same disturbing good looks. But his hair was straight, not wavy, and his eyes were black as midnight, and his mouth was cruel. He turned his head slowly back to look at her, and she saw blood rising in the cheek she'd slapped. â€Å"Don't lie to me,† she said, her voice shaking. â€Å"I know who you are. I knowwhat you are. You killed Mr. Tanner last night. And now Stefan's disappeared.† â€Å"Has he?† â€Å"You know he has!† Damon smiled and then turned it off instantly. â€Å"I'm warning you; if you've hurt him – â€Å" â€Å"Then, what?† he said. â€Å"What will you do, Elena? Whatcan you do, against me?† Elena fell silent. For the first time, she realized that the wind had died away. The day had gone deadly quiet around them, as if they stood motionless at the center of some great circle of power. It seemed as if everything, the leaden sky, the oaks and purple beeches, the ground itself, was connected to him, as if he drew Power from all of it. He stood with his head tilted back slightly, his eyes fathomless and full of strange lights. â€Å"I don't know,† she whispered, â€Å"but I'll find something. Believe me.† â€Å"I do believe you,† he said, relaxing, looking around the graveyard. Then he turned back and held out a hand to her. â€Å"You're too good for my brother,† he said casually. Elena thought of slapping the hand away, but she didn't want to touch him again. â€Å"Tell me where he is.† â€Å"Later, possibly – for a price.† He withdrew his hand, just as Elena realized that on it he wore a ring like Stefan's: silver and lapis lazuli. Remember that, she thought fiercely. It's important. â€Å"My brother,† he went on, â€Å"is a fool. He thinks that because you look like Katherine you're weak and easily led like her. But he's wrong. I could feel your anger from the other side of town. I can feel it now, a white light like the desert sun. You have strength, Elena, even as you are. But you could be so much stronger†¦Ã¢â‚¬  She stared at him, not understanding, not liking the change of subject. â€Å"I don't know what you're talking about. And what has it got to do with Stefan?† â€Å"I'm talking about Power, Elena.† Suddenly, he stepped close to her, his eyes fixed on hers, his voice soft and urgent. â€Å"You've tried everything else, and nothing has satisfied you. You're the girl who has everything, but there's always been something just out of your reach, something you need desperately and can't have. That's what I'm offering you. Power. Eternal life. And feelings you've never felt before.† Shedid understand then, and bile rose in her throat. She choked on horror and repudiation. â€Å"No.† â€Å"Why not?† he whispered. â€Å"Why not try it, Elena? Be honest. Isn't there a part of you that wants to?† His dark eyes were full of a heat and intensity that held her transfixed, unable to look away. â€Å"I can waken things inside you that have been sleeping all your life. You're strong enough to live in the dark, to glory in it. You can become a queen of the shadows. Why not take that Power, Elena? Let me help you take it.† â€Å"No,† she said, wrenching her eyes away from his. She wouldn't look at him, wouldn't let him do this to her. She wouldn't let him make her forget†¦ make her forget†¦ â€Å"It's the ultimate secret, Elena,† he said. His voice was as caressing as the fingertips that touched her throat. â€Å"You'll be happy as never before.† There was something terribly important she must remember. He was using Power to make her forget it, but she wouldn't let him make her forget†¦ â€Å"And we'll be together, you and I.† The cool fingertips stroked the side of her neck, slipping under the collar of her sweater. â€Å"Just the two of us, forever.† There was a sudden twinge of pain as his fingers brushed two tiny wounds in the flesh of her neck, and her mind cleared. Make her forget†¦Stefan. That was what he wanted to drive out of her mind. The memory of Stefan, of his green eyes and his smile that always had sadness lurking behind it. But nothing could force Stefan out of her thoughts now, â€Å"I've already found what I want,† she said brutally. â€Å"And who I want to be with forever.† Blackness welled up in his eyes, a cold rage that swept through the air between them. Looking into those eyes, Elena thought of a cobra about to strike. â€Å"Don't you be as stupid as my brother is,† he said. â€Å"Or I might have to treat you the same way.† She was frightened now. She couldn't help it, not with cold pouring into her, chilling her bones. The wind was picking up again, the branches tossing. â€Å"Tell me where he is, Damon.† â€Å"At this moment? I don't know. Can't you stop thinking about him for an instant?† â€Å"No!† She shuddered, hair lashing about her face again. â€Å"And that's your final answer, today? Be very sure you want to play this game with me, Elena. The consequences are nothing to laugh about.† â€Å"Iam sure.† She had to stop him before he got to her again. â€Å"And you can't intimidate me, Damon, or haven't you noticed? The moment Stefan told me what you were, what you'd done, you lost any power you might have had over me. Ihate you. You disgust me. And there's nothing you can do to me, not any more.† His face altered, the sensuousness twisting and freezing, becoming cruel and bitterly hard. He laughed, but this laugh went on and on. â€Å"Nothing?† he said. â€Å"I can doanything to you, and to the ones you love. You have no idea, Elena, of what I can do. But you'll learn.† He stepped back, and the wind cut through Elena like a knife. Her vision seemed to be blurring; it was as if flecks of brightness filled the air in front of her eyes. â€Å"Winter is coming, Elena,† he said, and his voice was clear and chilling even over the howl of the wind. â€Å"An unforgiving season. Before it comes, you'll have learned what I can and can't do. Before winter is here, you'll have joined me. You'll be mine.† The swirling whiteness was blinding her, and she could no longer see the dark bulk of his figure. Now even his voice was fading. She hugged herself with her arms, head bent down, her whole body shaking. She whispered, â€Å"Stefan – â€Å" â€Å"Oh, and one more thing,† Damon's voice came back. â€Å"You asked earlier about my brother. Don't bother looking for him, Elena. I killed him last night.† Her head jerked up, but there was nothing to see, only the dizzying whiteness, which burned her nose and cheeks and clogged her eyelashes. It was only then, as the fine grains settled on her skin, that she realized what they were: snowflakes. It was snowing on the first of November. Overhead, the sun was gone.

Narrative Essay on a Love Story to Tell Creative Ideas of Narration

Narrative Essay on a Love Story to Tell Creative Ideas of Narration The atmosphere was simply breathtaking: the sun was shining brightly over the calm suburbs. Being a few minutes past midday, most people were indoors, most probably taking their lunch or afternoon naps. In his room, Kevin sat on the bed, glum and heartbroken. His room was all messed up, with fashion magazines littered all over the carpeted floor. On one corner, there lay empty tins of hair gel and perfume bottles. The sight of these immediately brought back memories of Anne, the girl Kevin had loved with all his heart. His memories were jolted back to the time they first met. It was during a high school dance, and amidst all the other girls in attendance, Anne simply stood out. Her blue eyes were the most beautiful Kevin had ever seen. Her charm was amplified by the curly hair that was neatly tucked in a high, bouncy ponytail. Tall and slender, Anne had lovely dimples that any man would have given up anything for. With that first glimpse of her, Kevin was rendered speechless. Instead of approaching her and declaring his immediate thoughts and feelings, he simply shook her hand and walked away. He could not find the right words to describe his emotions at the time. Thankfully, he managed to get her number from a schoolmate; three days later, he called and expressed his interest in seeing her. Anne’s response was apparently encouraging; she had promised to think about Kevin’s proposal to meet with her and to keep in touch. But on this day, a full week since the promise, Kevin was a disheartened young man. Staring idly into space, he wondered why Anne’s response was not forthcoming. His face was covered with perspiration at the thought that perhaps Anne did not feel the same passion he felt for her. As the wind grew stronger, Kevin’s demeanor was equally becoming more intense. Almost abruptly, he arose from his bed and began kicking everything in his path. At this point, he spotted a small bottle on which were written the words â€Å"Rat and mice killer.† Convinced that life had deprived him of the one girl he wanted to be with most, he took the poison in one big gulp. The news spread like bushfire, and the local ambulance was at the door of his room in no time. Anne’s eyes were all teary as she implored Kevin to hang on, that she loved him and was ready to become his girlfriend. As fate would have it, Kevin opened his mouth but speech failed him as he fell lifeless onto the floor. Anne wept uncontrollably; playing hard to get had been unimaginably costly to her. Dark clouds gathered in the sky as Kevin’s body was taken away. Tips on narrative essay writing: As is evident from this sample essay, narrative essays on love are very intriguing, both to the reader and the writer. Anyone can write a narrative essay on love, provided he or she is creative enough. For one who enjoys romantic novels and has some creative ideas of his own, such an essay can be completed within a few minutes. A useful tip when writing a narrative essay on love is to base it on everyday happenings. For example, the essay can center on unreciprocated or one-sided love. Like all other narratives, this type of essay should involve some elements of fiction, such as use of pseudonyms in place of real names.

The Content Creator That You’ve Always Wanted Is Here - CoSchedule

The Content Creator That You’ve Always Wanted Is Here Back in March I started making calls. Tons of them. The recipient? You. Since this past April, I’ve talked to more than 100 different customers or potential customers that were trying our product for the first time. I learned a few things. There are a lot of marketing projects, and teams, that need organizing. There are even more spreadsheets that still need eliminating. There was a lot more that we could do here at to make your life way easier. Like waaaaaaay easier.   So, we began what has became known as the â€Å"Content UX† project here inside of , which was short for â€Å"content user experience.† It was a cumulation of everything that I learned on those calls. The goal was to make the experience of editing and managing content inside of easier and even more team-oriented. In short, we want to eliminate your spreadsheets and clumsy workarounds. The Content UX project was born, and we  made our first code changes in July. Today you finally get to use version 1.0. We’re pumped! Here are three big changes that roll out today, plus a few amazing new features that are up next. For a detailed look at every change launching today, please see this post. Here, I will be covering the bigger goals behind the features. Change #1: We Hid The Things You Didn’t Need One of the problems we wanted to address was the â€Å"clutter† that had taken place in the content creator.  As we’ve added new features, we’ve been forced to augment our existing design which wasn’t built to handle all of that power.   We’ve made it work, but it’s was ultimately time for something better. is powerful, but that doesn’t mean it needs to look complicated. #ui #redesignWith this redesign we wanted to accomplish a couple things: Hide things that you didn’t need. A few examples of this include making the headline analyzer an optional integration, along with the social queue itself (which has been renamed to Social Campaigns). Utilize the entire screen. Our new â€Å"full-screen† editing experience on the calendar gives you the space you need to do your best work. I think the results speak for themselves. The interface is cleaner, more user-friendly, and better organized around keeping your entire marketing process right on track. Change #2: We Made Even More Team Friendly Teamwork is important. To make it easier for teams to work together, we’ve added an all-new sidebar to manage all of your project activity. Tasks, comments, and team contributors are now managed in separate tabs rather than our long long-running lists.  This redesign will prevent the excessive scrolling that sometime came with larger projects. Additionally, we’ve introduced some major updates to our task management features such as the addition of unscheduled tasks, drag and drop task sorting, and an all-new â€Å"files† tab which will be launching soon. The new activity sidebar also does a better job of reporting new activity and clearing out older comments and data that are no longer as relevant. Some of our users have reported that on-boarding new team members to can be a challenge. We hope that these changes start making that process much easier. Change #3: Make Content Creation Easier   The content editor in has undergone an extreme makeover. First, we’ve completely replaced the built-in text editor with a brand new version. The new editor supports more formatting and is far more reliable than our previous solution. Creating content inside of should now be a seamless experience. Second, we added some clarity to the editor selection process, which we learned was a regular source of confusion. Now, when you create a new piece of content in you will be asked to select a single editing mode. The options include: Our *NEW* built-in text editor Google Docs Evernote WordPress File upload (Microsoft Word, images, etc.) Of course, many of you love to create and edit your content in Microsoft Word, and we’ve even added some great new features just for you. File Version Control Now, when editing our content using a traditional word processor like Microsoft Word, team members can download the file, make changes, and then re-upload the file as a new version. will maintain a history of all previous versions, which can be accessed at any time.  Everyone on the team will see that edits have been made, and will have access to a full file history. It’s the best way to bring a real-time like workflow to those tools that aren’t quite real time! Soon, we’ll also be adding support for converting Word Docs into WordPress Blog posts, so be on the lookout for that update. New to : File Version Control.Change #4, #5, #6, and #7: Coming Soon! We have a lot more in store for our content creator – all based on your suggestions. Here are a few of the things that are up next. Custom Content Types We will be rolling out an update in a few weeks that will allow you to customize the menu you use to add new content to . Fill it up as much or as little as you want. Further down the road we hope to add even more ways to create custom content types as a way to separate your content. Multiple Color Labels This feature will allow you to select multiple color labels for each piece of  content you create. This overhaul will also include the ability to add your own custom labels. Tags! Tags! Tags! Wouldn’t it be great if you could add tags to each piece of content you create for further customization? We think so too. Look for this to ship soon. Marketing Projects This feature will allow you to combine several different pieces of content or social campaigns into a single project. With this update you’ll be able to manage even the most complex of marketing projects from . Look for this one early 2017. And More! Of course, there’s a lot more to come that we aren’t ready to share. Please keep your features requests coming as well. We are always on the look out for the next big thing!

UK Revised Combined Code Essay Example | Topics and Well Written Essays - 3000 words

UK Revised Combined Code - Essay Example Following the Enron report, two review committees were commissioned by the UK Financial Reporting Council (FRC) to review UK corporate governance2. The two independent review reports - the Higgs Report on Non-Executive Directors and the Smith Report on Audit Committees, were published in January 2003 and form the bases for the revised Code [also see Higgs review (2003) and Smith review (2003)]. In this analysis the features of the revised combined code will be discussed along with studies to show and suggest whether the implementation of this code is likely to improve the effectiveness of corporate governance for listed companies. The revised code contains 14 principles for companies supported by 48 code provisions. Many aspects of the revised code have remained unchanged from the original code although there have been many important changes. The code suggests that the board should comprise of independent non-executive directors along with executive directors and the code contains guidance on the meaning of independent directors emphasizing on independence as an important measure (Long et al, 2005). It also lays down the rule that the role of chairman and chief executive should not be a position taken by the same person (in Combined Code, 2003). The chairman should be independent and only in certain exceptional cases, the chairman can also be a former chief executive. It has also been suggested that the position of a senior independent non-executive director should be included. This new position of senior independent non-executive director shows that the director must be identified in the annual report and al so be given specific responsibilities (Long et al, 2005). The other specifications of the revised code show that all listed companies should have an audit committee, a nomination committee and a remuneration committee. The audit and remuneration committees should have at least three members and all the members should be independent non executive directors3. The majority of the members are expected to be independent non executive directors and the committee is also headed by the chairman who is an independent non executive director (Long et al, 2005; Chambers 2005)4. The code also specifies that at least one member of the audit committee must be a financial expert or a person with the relevant financial experience and having membership with a professional accountancy body. The code highlights on performance evaluation and regular monitoring and emphasises on the performance evaluation of board members and the committees and executive directors (Combined Code, 2003; Directors' Remuneration Report, 2002). The annual report should include a disclosure on the performance evaluation process. The external auditors are important as well and the audit committee is given the primary responsibility of making a recommendation on the appointment, reappointment and removal of external auditors. The audit committee is given the responsibility to develop and implement policy on engagement or taking services of the external auditor to supply non-audit services. The Audit Committee states in its report that the

Study case Essay Example | Topics and Well Written Essays - 2750 words - 1

Study case - Essay Example For the information strategy to work effectively the only requirement is that information should not be biased and should be obtained using utmost care and analysis. In the case at hand, the information will be obtained from the employees and the board members of the company. The IT development team will conduct user surveys and review user requirements individually (Hansen et all, 1999). They will strive to find out the roles played by each employee and will design a system that enables each individual to perform his or her role effectively. Similarly, the IT consultants will have to analyze the different use cases and the user scenarios which will affect the end product. The information needs will then be derived from the use cases. From the case the business requirements are to provide an online marketplace for buyers and customers to interact, place orders, enter details and feedback and receive goods through a logistics channel. Hence, Aalsmeer has to function in a manner where it not only keeps record of the financial transactions of the company but also the financial transactions that take place over their marketplace. Similarly, for their success they will have to market their offering to the customers which can be flower growers and flower merchants as well as the private buyers who want flowers and plants to be delivered to them for a non business purpose. In addition to this the Flower Auction will have to incorporate the feedback from the clients to the vendors so that the growers know what is being demanded in the marketplace and grow the same flowers and plants. Therefore, it will provide the growers the analysis of the demand in the market for the various types of plants and flowers. The information requirements for the proposed system can be divided into different entities. There would be different information stored for individual entities, i.e. growers and sellers would have their profile while the customers will have one